New Study Shows Effects of Medicinal Mushroom Extract on Pancreatic Cancer Cells

Source Press Release
Company Indiana University 
Tags Oncology
Date May 20, 2013

New Study Shows Effects of Medicinal Mushroom Extract on Pancreatic Cancer Cells

Groundbreaking research published in International Journal of Oncology

SAN FRANCISCO, May 20, 2013 /PRNewswire/ -- A study published in the June issue of the  International Journal of Oncology found that  Poria  Triterpine Extract (PTE ), a mixture of triterpines from Poria  cocos , a medicinal mushroom  used in traditional Asian medicine, suppress the proliferation of human pancreatic cancer cell lines.

Pancreatic cancer has some of the poorest survival rates among all types of cancer. It is rarely diagnosed early enough for successful intervention, and complete remissions are extremely rare.

The research was led by Dan Sliva, Ph.D., and performed at the Cancer Research Laboratory at  Methodist  Research Institute, Indiana University Health.  Isaac Eliaz, MD, LAc, the director of Amitabha Medical Clinic & Healing Center, coauthored the study as part of his ongoing research into adjunctive anticancer therapies."

This is truly a groundbreaking study that could make a significant impact on the treatment of pancreatic cancer, the fourth-leading cause of cancer-related deaths in the United States," said Dr. Eliaz. "This is a particularly devastating disease, with a survival rate of about 5 percent over five years. With this study, we have made a great deal of progress toward potentially using PTE  to treat pancreatic cancer."

According to the study, the anti-proliferative effects of PTE  on BxPc-3 cells, a primary human pancreatic tumor cell line, are mediated by the cell cycle arrest at the G0/G1 phase, the resting phase where the cell has left the cell growth cycle and has stopped dividing. DNA microarray analysis also demonstrated that  PTE  significantly down-regulates the expression of  KRAS , a tissue signaling  protein that acts as an "on switch" for cancer cell propagation, as well as matrix  metalloproteinase -7 (MMP-7), an enzyme involved in physiological functions and disease progression such as cancer metastasis .

Additionally, the study found that PTE  suppresses the invasiveness of pancreatic cancer cells, which was associated with the reduction of MMP-7. In analysis, the gene silencing of MMP-7, which also suppressed the invasiveness of the pancreatic cancer cells, further confirmed this conclusion.

As a result of the study, researchers found that PTE  outperformed pachymic acid, a single derivative of  Poria  cocos . Further studies are now in progress to investigate the exact mechanism of the inhibition of MMP-7 expression and further evaluation of the anticancer and anti-metastatic activity of PTE .

Dr. Eliaz, MD, MS, LAc, has coauthored a number of peer-reviewed scientific studies on natural formulations against cancer, heavy metal toxicity and chronic illness. Amitabha Medical Clinic & Healing Center is an integrative  medical clinic in  Santa  Rosa , California, that focuses on treating patients with cancer and chronic illnesses. To learn more, visit http://www.amitabhaclinic.com.

Source: Cheng S, Eliaz I, Lin J, Sliva D. Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7. Int J Oncol. 2013 Jun;42(6):1869-74. doi: 10.3892/ijo.2013.1902. Epub 2013 Apr 16.

SOURCE  Better Health Publishing

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